Polo-Like Kinase Kinase (PLKK) is a 120kD protein that belongs to the serine/threonine kinase family. It has a crucial role in regulating cellular events in cytokinesis and mitosis. Anti-phospho-polo-like kinase kinase (pSer482, pSer486, pSer490) antibody can be used in immunoblotting (diluted 1:1000). Rabbit anti- phospho-polo-like kinase kinase antibody reacts specifically with phospho-polo-like kinase kinase of xenopus.
Immunogen
synthetic phosphopeptide corresponding to amino acids residues surrounding the Xenopus polo-like kinase kinase phosphorylated on serines 482, 486 and 490.
Application
Anti-phospho-polo-like kinase kinase (pSer482, pSer486, pSer490) antibody can be used in western blotting (diluted 1:1000).
Physical form
Solution in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.
Science (New York, N.Y.), 282(5394), 1701-1704 (1998-11-30)
The Xenopus polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. Polo-like kinases from various organisms are activated by phosphorylation by an unidentified protein kinase. A protein kinase
Calcium signaling is emerging as a key pathway controlling cellular senescence, a stable cell proliferation arrest playing a fundamental role in pathophysiological conditions, such as embryonic development, wound healing, cancer, and aging. However, how calcium signaling is regulated is still
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