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P2110

Sigma-Aldrich

Anti-Platelet-Derived Growth Factor Receptor α antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-PDGF Rα

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About This Item

MDL number:
MFCD03444647
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

direct ELISA: 0.5-1.0 μg/mL
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL using human tissue sections
neutralization: suitable
western blot: 0.1-0.2 μg/mL

UniProt accession no.

P16234

storage temp.

−20°C

Gene Information

human ... PDGFRA(5156)

General description

Blocks cell surface human or mouse PDGF Receptor α mediated biological activity induced by PDGF-AA.

Immunogen

recombinant soluble human platelet-derived growth factor receptor α expressed in Sf 21 cells.

Biochem/physiol Actions

Platelet-derived growth factor (PDGF) is a serum growth factor purified from human platelets. The cellular effects of PDGF are mediated by binding to PDGF α- and PDGF β-receptors which leads to activation of downstream signaling via PI3K, STAT and Ras/MAPK. PDGFR stimulates the proliferation of cells of connective tissue and glial cells, survival, differentiation, chemotaxis and wound healing.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Noortje A M Bax et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(10), 2658-2669 (2009-08-26)
For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role
Nynke M S Van Den Akker et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(4), 1579-1588 (2005-06-24)
Platelet-derived growth factors (PDGFs) are important in embryonic development. To elucidate their role in avian heart and coronary development, we investigated protein expression patterns of PDGF-A, PDGF-B, and the receptors PDGFR-alpha and PDGFR-beta using immunohistochemistry on sections of pro-epicardial quail-chicken
Johanna Andrae et al.
Genes & development, 22(10), 1276-1312 (2008-05-17)
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in
Carl-Henrik Heldin
Upsala journal of medical sciences, 117(2), 83-91 (2012-04-20)
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and

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