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P1411

Sigma-Aldrich

Polymyxin B-Agarose

aqueous glycerol suspension

Synonym(s):

PMB

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About This Item

MDL number:
MFCD00165491
UNSPSC Code:
41106500
NACRES:
NA.56

biological source

synthetic (organic)

Quality Level

200

form

aqueous glycerol suspension

extent of labeling

~1 mg per mL

technique(s)

affinity chromatography: suitable

matrix

Cross-linked 4% beaded agarose

matrix activation

cyanogen bromide

matrix attachment

amino

matrix spacer

1 atom

capacity

200-500 μg/mL binding capacity (lipopolysaccharide)(from Escherichia coli serotype 0128:B12)

suitability

suitable for chromatography

storage temp.

2-8°C

Application

Polymyxin B-agarose is used in protein chromatography, affinity chromatography and specialty resins. Polymyxin B-agarose has been used to study periodontitis and endodontic infections as well as obesity and type 2 diabetes.
Useful for removal of endotoxins from solutions

Physical form

Suspension in 50% glycerol containing 0.02% sodium azide

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Samira B R Prado et al.
Scientific reports, 10(1), 1690-1690 (2020-02-06)
Dietary fibers have been shown to exert immune effects via interaction with pattern recognition receptors (PRR) such as toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors. Pectin is a dietary fiber that interacts with PRR depending on its chemical
L F Weikert et al.
American journal of physiology. Lung cellular and molecular physiology, 279(2), L216-L223 (2000-08-05)
Surfactant-associated protein A (SP-A) is involved in surfactant homeostasis and host defense in the lung. We have previously demonstrated that SP-A specifically binds to and enhances the ingestion of bacillus Calmette-Guerin (BCG) organisms by macrophages. In the current study, we
K Stuhlmeier et al.
Clinical and experimental immunology, 84(2), 317-323 (1991-05-01)
Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum. Under serum-free conditions, almost no
A C Issekutz
Journal of immunological methods, 61(3), 275-281 (1983-07-29)
Endotoxins liberated by gram-negative bacteria are frequent contaminants of aqueous and physiological solutions. Because of their potent biological effects in vivo and in vitro, it is often necessary to eliminate even minute quantities of endotoxin from such solutions. A process
P J Jagielo et al.
The American journal of physiology, 270(6 Pt 1), L1052-L1059 (1996-06-01)
To investigate the role of endotoxin in grain dust-induced airway inflammation, we reduced the endotoxin activity from extracts of corn dust (CDE), using three distinct methods, and determined the effect of endotoxin activity on the in vitro and in vivo
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