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P0778

Pindolol

≥98% (TLC), β1-adrenoceptor antagonist, powder

Synonym(s):

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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250 MG

$107.00

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$146.00

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About This Item

Empirical Formula (Hill Notation):
C14H20N2O2
CAS Number:
13523-86-9
Molecular Weight:
248.32
NACRES:
NA.77
PubChem Substance ID:
24277795
UNSPSC Code:
12352200
EC Number:
236-867-9
MDL number:
MFCD00010530
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

Key Documents

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Product Name

Pindolol, ≥98% (TLC), powder

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

167-171 °C (lit.)

solubility

0.1 M NaOH: 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, acetic acid: 50 mg/mL, H2O: insoluble

originator

Novartis

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

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Show Differences

1 of 4

This Item
P8688SML1913P0884
Pindolol ≥98% (TLC), powder

Sigma-Aldrich

P0778

Pindolol

(S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder

Sigma-Aldrich

P8688

(S)-(−)-Propranolol hydrochloride

ASB14780 ≥98% (HPLC)

Sigma-Aldrich

SML1913

ASB14780

(±)-Propranolol hydrochloride ≥99% (TLC), powder

Sigma-Aldrich

P0884

(±)-Propranolol hydrochloride

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥99% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

0.1 M NaOH: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, H2O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, acetic acid: 50 mg/mL

solubility

ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H2O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H2O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

color

white to off-white

color

-

color

white to beige

color

white

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.
β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

Features and Benefits

Shelf-life of the powder is at least five years.
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000545746
0000545744
0000545744
0000494968
0000443243

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The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
Williams E T, et al.
Drug Metabolism and Disposition (2008)
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts
Pelkonen L, et al.
European Journal of Pharmaceutical Sciences, 162-168 (2017)
Pindolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects
Golightly L K
Pharmacotherapy, 2(3), 134-147 (1982)
C M Hysek et al.
Emergency medicine journal : EMJ, 27(8), 586-589 (2010-04-10)
MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') produces tachycardia and hypertension and is rarely associated with cardiovascular and cerebrovascular complications. In clinical practice, beta-blockers are often withheld in patients with stimulant intoxication because they may increase hypertension and coronary artery vasospasm due to loss
Maria J Portella et al.
The Journal of clinical psychiatry, 72(7), 962-969 (2010-11-03)
Since depression entails not only dramatic personal disruption but also a huge amount of medical and socioeconomic burden, slowness of antidepressant action and difficulties to attain remission are entangled issues to be solved. Given the controversial previous findings with enhancing
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Global Trade Item Number

SKUGTIN
P0778-250MG04061832083520
P0778-1G04061825982601

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