The PTX3 (pentraxin 3) gene is mapped to human chromosome 3q25.32. The protein is localized in mesenchymal cells, endothelial cells of vascular tissue, fibroblasts, monocytes and granulocytes.
Immunogen
a synthetic peptide corresponding to human PTX3 (amino acids 110-124) conjugated to BSA.
Application
Anti-PTX3 antibody produced in rabbit has been used in immunofluorescence and immunohistochemistry.
Biochem/physiol Actions
PTX3 (pentraxin 3) is associated with humoral immune response and inflammatory processes, and therefore offers protection against pathogenic antigens. Proinflammatory cytokines, microbes and signals derived from damaged tissue triggers the expression of the gene upon stimulation. It serves as a biomarker for a number of inflammatory vascular and autoimmune disorders, including vasculitis, rheumatoid arthritis, psoriasis, and cardiovascular diseases. PTX3 is involved in tumor progression by participating in proliferation and invasion steps, which were observed in glioma.
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Growth arrest specific-1 (GAS1) is a C/EBP target gene that functions in ovulation and corpus luteum formation in mice.
Ren Y A, et al.
Biology of Reproduction, 94(2), 44-41 (2016)
Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation.
Dander E, et al.
Oncotarget, 7(50), 82123-82123 (2016)
Evaluation of the association of plasma pentraxin 3 levels with type 2 diabetes and diabetic nephropathy in a Malay population.
Abu Seman N, et al.
Journal of Diabetes Research, 2013 (2013)
Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo.
Tung J N, et al.
Journal of Neuro-Oncology, 129(2), 201-209 (2016)
Long pentraxin 3: a marker of inflammation in untreated psoriatic patients.
Bevelacqua V, et al.
International Journal of Molecular Medicine, 18(3), 415-423 (2006)
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