PKR is a double-stranded RNA-dependent serine/threonine kinase that regulates antiproliferative and antiviral functions of interferons. PKR also functions as a translational inhibitor. In genotoxic environments, PKR mediates CDC2 ubiquitination and G2 arrest in cells . Anti-PKR is antibody is specific for human PKR (68 kDa).
Immunogen
C-terminus of human PKR (amino acids 531-550), conjugated to KLH
Application
Anti-PKR (ET-20) antibody I suitable for use in western blot (1:2,000 using a whole cell extract of the human epitheloid carcinoma HeLa cell line induced with interferon-γ) and microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 18(8), 609-616 (1998-09-03)
The double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine kinase that plays an important role in the antiviral activities of interferon (IFN). To determine the organization and regulation of the PKR locus, lambda phage and bacterial artificial chromosome (BAC) clones
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
The double-stranded RNA-dependent protein kinase PKR is an interferon-inducible enzyme that possesses antiviral and antiproliferative activities. We examined expression of PKR transcripts in human placenta tissue and cultured human amnion U cells. Alternative exon 2 structures were identified and characterized
A model is presented for the regulation of the double-stranded RNA (dsRNA)-activated mammalian protein kinase PKR, which is involved in protein synthesis inhibition and the antiviral response in cells. A series of previous findings abut PKROs behavior are reviewed, including
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
