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P0240

Sigma-Aldrich

PRAK Substrate Peptide

1 mg/mL in H2O, ≥98% (HPLC), aqueous solution

Synonym(s):

P38 Regulated/Activated Protein Kinase Substrate Peptide

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About This Item

MDL number:
MFCD02682926
UNSPSC Code:
12352202
PubChem Substance ID:
329820024
NACRES:
NA.77

Quality Level

200

assay

≥98% (HPLC)

form

aqueous solution

mol wt

1171 by amino acid sequence

concentration

1 mg/mL in H2O

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(O)=O

InChI

1S/C51H98N18O13/c1-26(2)23-35(65-42(74)32(16-10-12-20-53)62-40(72)31(54)15-9-11-19-52)44(76)64-33(17-13-21-59-50(55)56)41(73)63-34(18-14-22-60-51(57)58)43(75)69-39(30(8)71)48(80)66-36(24-27(3)4)45(77)67-37(25-70)46(78)68-38(28(5)6)47(79)61-29(7)49(81)82/h26-39,70-71H,9-25,52-54H2,1-8H3,(H,61,79)(H,62,72)(H,63,73)(H,64,76)(H,65,74)(H,66,80)(H,67,77)(H,68,78)(H,69,75)(H,81,82)(H4,55,56,59)(H4,57,58,60)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

InChI key

QDSZECPRZNYZJS-DVHCFKBKSA-N

Amino Acid Sequence

Lys-Lys-Leu-Arg-Arg-Thr-Leu-Ser-Val-Ala

Biochem/physiol Actions

Peptide substrate for the enzyme PRAK (P38 regulated/activated protein kinase)

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
071K1456

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L New et al.
The EMBO journal, 17(12), 3372-3384 (1998-06-17)
We have identified and cloned a novel serine/ threonine kinase, p38-regulated/activated protein kinase (PRAK). PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAP-K2/3. PRAK was found to

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