peptide DRFLKIIRPLRNIFLK(C) corresponding to residues 119-134 of human P2Y13 receptor.
Target description
P2Y13 receptor belongs to the G-protein coupled receptors superfamily. Like the P2Y12 receptor it is a high affinity receptor for the ADP nucleotide, coupled to the Gai class of G-proteins. The P2Y13 receptor is highly expressed at brain and spleen tissues as well as in the immune system. ADP activates a negative feedback pathway for ATP release from human red blood cells via the P2Y13 receptor. P2Y13 receptor was also implicated in inhibition of N-type Ca2+ channels in neurons, exerting pre and/or post-synaptic modulatory action.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
Reconstitution
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
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Journal of medical primatology, 52(6), 405-413 (2023-10-18)
Endometriosis is the presence of endometrium-like tissue outside the uterine cavity. An experimental model of endometriosis has been created in the baboon by the transcervical collection and laparoscopic inoculation of menstrual endometrium. Macaques are the preferred model for pharmaceutical development
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