peptide (C)KRRAIRLANSTAS, corresponding to residues 538-550 of the human Kv4.1.The epitope is localized intracellularly in C-terminal.
Target description
The Kv4 channels are characterized by activation at subthreshold membrane potentials, inactivate rapidly and recover from inactivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predominantly of the A-type and attributable to coexpression of Kv4.1 and Kv4.2 subunits.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.
Reconstitution
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
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Caenorhabditis elegans provides an amenable system to explore whether newly composed ribosomes are required to progress through development. Despite the complex pattern of tissues that are formed during embryonic development, we found that null homozygotes lacking any of the five
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