N9532
Monoclonal Anti-Nitric Oxide Synthase, Endothelial antibody produced in mouse
clone NOS-E1, ascites fluid
Synonym(s):
Anti-eNOS
Sign Into View Organizational & Contract Pricing
Select a Size
0.2 ML
$504.90
$504.90
List Price$561.00Save 10%Web-Only Promotion
Available to ship onMay 01, 2025Details
A recombinant, preservative-free antibody is available for your target. Try ZRB1252
Request a Bulk Order
All Photos(1)
Select a Size
Change View
0.2 ML
$504.90
About This Item
$504.90
List Price$561.00Save 10%Web-Only Promotion
Available to ship onMay 01, 2025Details
A recombinant, preservative-free antibody is available for your target. Try ZRB1252
Request a Bulk Order
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
NOS-E1, monoclonal
mol wt
antigen 135 kDa
contains
15 mM sodium azide
species reactivity
rat, mouse, human, bovine
technique(s)
microarray: suitable
western blot: 1:3,000 using whole cell extract of cultured bovine lung endothelial cells
isotype
IgA
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOS3(4846)
mouse ... Nos3(18127)
rat ... Nos3(24600)
Related Categories
General description
Monoclonal Anti-Nitric Oxide Synthase, endothelial (eNOS) (mouse IgA isotype) is derived from the NOS-E1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. NOS consists of heme and calmodulin binding sites located within its N-terminal half. It has been localized in many different cell types. Based on molecular mass, subcellular location and Ca2+ dependence, at least three types of NOS have been classified. Type I NOS (150-160 kD protein) is found in neurons and is also called as neuronal NOS (nNOS), brain NOS (bNOS), cerebral NOS, constitutive NOS or Ca2+-regulated NOS (cNOS). Type II (130 kD protein) is found in macrophages and is also known as macrophage NOS (mNOS) or inducible NOS (iNOS). Type III (135 kD protein) is found in endothelial cells and is also called endothelial NOS (eNOS or ecNOS).
The gene encoding endothelial nitric oxide synthase (eNOS) is localized on chromosome 7q35-36 and has 26 exons.
Immunogen
synthetic peptide corresponding to nitric oxide synthase (NOS) from bovine endothelial origin (eNOS, amino acids 1185-1205 with an N-terminally added lysine) conjugated to KLH. The immunogen sequence is highly conserved in human eNOS.
Application
Monoclonal Anti-Nitric Oxide Synthase, Endothelial (eNOS) has been used:
- for enzyme linked immunosorbent assay (ELISA)
- immunoblot
- immunohistochemistry
- immunofluorescence.
Monoclonal Anti-Nitric Oxide Synthase, Endothelial antibody produced in mouse has been used in antibody microarray.
Biochem/physiol Actions
Endothelial nitric oxide synthase (eNOS) has been studied as a modulator of vascular function and it is involved in the production of nitric oxide. Defects in the enzyme expression have been shown to be associated with coronary artery disease.
NOS catalyses the oxidation of guanidino nitrogen of arginine. The released nitric oxide mediates vasodilatation, neurotransmission, and antimicrobial and anti-tumor activities. NOS is associated with multiple sclerosis and allergic encephalomyelitis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
recommended
Product No.
Description
Pricing
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Xiaofei Zhu et al.
The journal of gene medicine, 26(7), e3718-e3718 (2024-07-09)
Icariin (ICA) inhibits inflammatory response in various diseases, but the mechanism underlying ICA treating airway inflammation in asthma needs further understood. We aimed to predict and validate the potential targets of ICA against asthma-associated airway inflammation using network pharmacology and
Feng-Yen Lin et al.
Journal of immunology (Baltimore, Md. : 1950), 186(7), 4405-4414 (2011-03-09)
Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) plays a major role in oxidized low-density lipoprotein-induced vascular inflammation. Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis, although its specific mechanism remains unknown. This study was
Contribution of eNOS variants to the genetic susceptibility of coronary artery disease in a Tunisian population.
Ben Ali M
Genetic Testing and Molecular Biomarkers (2015)
Ana Rosa Cunha et al.
International journal of experimental pathology, 89(4), 284-291 (2008-08-22)
The influence of hyperglycaemia on nephrogenesis on Swiss mice pups treated with streptozotocin (STZ) (40 mg/kg, i.p.) was studied after birth, at 7 and 21 days. Kidneys were prepared for light microscopy, immunohistochemistry and stereology. In 7-day-old pups, both immature
Enzymes of the L-arginine to nitric oxide pathway
Stuehr DJ
The Journal of Nutrition, 134(10), 2748S-2751S (2004)
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
