N9413

NSC 295642

≥98% (HPLC), solid

• Synonym(s): Bis-[chloro[phenylmethyl [1-(2-pyridinyl)ethylidene]hydrazinecarbodithioato-N2,N2′,S1’]-copper], Cu(II) complex of the Schiff base product of condensation of S-benzyl dithiocarbazate and 2-acetylpyridine, [1-(2-pyridinyl)ethylidene]-Hydrazinecarbodithioic acid, phenylmethyl ester, copper complex
• Empirical Formula (Hill Notation): C₃₀H₂₈Cl₂Cu₂N₆S₄
• CAS Number: 77111-29-6
• Molecular Weight: 798.84
• UNSPSC Code: 12352202
• PubChem Substance ID: 329818694

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: dark green
• solubility: DMSO: >5 mg/mL
• SMILES string: C\C(=N/N=C(/SCc1ccccc1)S[Cu]Cl)c2ccccn2
• InChI: 1S/C15H15N3S2.ClH.Cu/c1-12(14-9-5-6-10-16-14)17-18-15(19)20-11-13-7-3-2-4-8-13;;/h2-10H,11H2,1H3,(H,18,19);1H;/q;;+2/p-2/b17-12+;;
• InChI key: MGXCRQNCPJBYKM-CWQUOYFRSA-L

Description

Biochem/physiol Actions

NSC 295642 is a potent inhibitor of cell migration. Cell migration is a basic biological process involved in a range of normal and pathological events, including wound healing, embryonic and tissue development, immune function and inflammation, angiogenesis and tumor metastasis. Therefore, cell migration can be adapted as an important biological tool to monitor several physiological processes as well as development of cancer. Accordingly, a potent inhibitor of cell migration, such as NSC 295642 can elucidate the intrinsic molecular mechanism of many biochemical events.

NSC 295642 is a potent inhibitor of cell migration. It is also a weak inhibitor of the phosphatase CDC25A.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves