N8539

Anti-NDRG1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-CAP43, Anti-CMT4D, Anti-DRG1, Anti-GC4, Anti-HMSNL, Anti-N-myc downstream regulated 1, Anti-NDR1 (differentiation-related gene 1 protein), Anti-NMSL, Anti-PROXY1 (protein regulated by oxygen 1), Anti-RIT42, Anti-RTP (reducing agents and tunicamycin-responsive protein), Anti-TARG1, TDD5
• MDL number: MFCD03454849
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~43 kDa
• species reactivity: mouse, human, rat
• packaging: antibody small pack of 25 μL
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 5-10 μg using lysates of HeLa cells; western blot: 1-2 μg/mL using whole extract of mouse 3T3 and rat NRK cells
• UniProt accession no.: Q92597
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NDRG1(10397)

Description

General description

N-myc downstream regulated 1 (NDRG1) is a member of the N-myc downregulated gene family that belongs to the alpha/beta hydrolase superfamily. In humans, this protein is mainly expressed in epithelial cells.

Application

Anti-NDRG1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

The cytoplasmic protein encoded by N-myc downstream regulated 1 (NDRG1) gene participates in stress responses, hormone responses, cell growth and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. NDRG1 is a Rab4a effector, that participates in vesicular recycling of E-cadherin.[1] It plays a key role in peripheral nervous system myelination. It also helps to modulate lipid fate in breast cancer cells.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable