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Key Documents

N6127

Sigma-Aldrich

19-Norethindrone acetate

Synonym(s):

17α-Ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate, 17α-Ethynyl-19-nortestosterone 17β-acetate, 17-Hydroxy-19-nor-17α-4-pregnen-20-yn-3-one acetate, 19-Norethisterone 17-acetate

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About This Item

Empirical Formula (Hill Notation):
C22H28O3
CAS Number:
Molecular Weight:
340.46
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

assay

≥98.00% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C

InChI

1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1

InChI key

IMONTRJLAWHYGT-ZCPXKWAGSA-N

Gene Information

human ... PGR(5241)

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pictograms

Health hazardEnvironment

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Anieta M Sieuwerts et al.
Molecular oncology, 5(6), 504-516 (2011-10-01)
Risk assessment of future breast cancer risk through exposure to sex steroids currently relies on clinical scorings such as mammographic density. Knowledge about the gene expression patterns in existing breast cancer tumors may be used to identify risk factors in
Marjo Tuppurainen et al.
Maturitas, 66(4), 423-430 (2010-06-16)
To determine the effects of HRT with or without clodronate on bone mineral density (BMD) change and bone turnover markers. Prospective, partly randomized trial. Kuopio University Hospital, Finland. 167 osteoporotic women (61+/-2.7 years; T-score<or=-2.5 SD). Estradiol 2 mg+NETA 1 mg
D J Kaser et al.
Journal of pediatric and adolescent gynecology, 25(2), 105-108 (2011-12-14)
To evaluate the efficacy and tolerability of norethindrone acetate (NA) as single-agent hormonal therapy for suppression of endometriosis symptoms in adolescents and young adults. Retrospective study. Two academic medical centers. A keyword search using the query 'NA' was applied to
Donita Africander et al.
Contraception, 84(4), 423-435 (2011-09-17)
Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been
E Lundström et al.
Maturitas, 70(4), 361-364 (2011-10-01)
To determine the effects of continuous combined hormone therapy, tibolone, black cohosh, and placebo on digitized mammographic breast density in postmenopausal women. A prospective, double-blind, placebo-controlled study of 154 postmenopausal women randomized to estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA)

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