Expert opinion on investigational drugs, 19(11), 1451-1459 (2010-09-28)
Alcohol use and dependence are frequent disorders. Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge. The opioidergic system plays a crucial role in mediating
Journal of drugs in dermatology : JDD, 10(8), 853-860 (2011-08-06)
To investigate the efficacy, safety and tolerability of topical nalmefene (SRD174), a long acting opioid antagonist for the management of pruritus associated with atopic dermatitis (AD). Double-blind, vehicle-controlled, randomized, cross-over trial. Eleven dermatology outpatient clinics in the U.S. Sixty-two out
[Serum NT-proBNP levels in neonates with severe asphyxia and the effects of nalmefene on the NT-proBNP levels].
Qian Zhang et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 12(11), 922-923 (2010-11-19)
Kappa(kappa) opioid agonists slow gastrointestinal transit in the guinea pig and the mouse but not the rat. Opioid antagonists naloxone and naltrexone are mu (mu) preferring, while the antagonist nalmefene has more kappa binding activity. When administered orally, the specific
Journal of chromatography. A, 1262, 214-218 (2012-09-25)
In the present work, pulsed electromembrane extraction (PEME) is introduced for the first time as an efficient and inexpensive method for the extraction of ionizable compounds from different matrices. The setup proposed for electromembrane extraction (EME) provides a very stable
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