N4538
Anti-Noggin antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-NOG
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... NOG(9241)
mouse ... Nog(18121)
rat ... Nog(25495)
General description
Noggin (NOG) is a protein first identified in Xenopus-italics that plays a vital role in the dorsal fate specification during embryogenesis. A similar protein was also found in mammals and is vital during the various processes of morphogenesis. Noggin is mainly expressed in specific regions of brain such as cerebellum, olfactory bulb, and the piriform cortex. It interacts with various transcription factors such as Wnt, Hox, Sox, Pax and Pou gene products. Noggin has been identified as an inhibitor of the TGF-β signalling pathway and is involved in neural induction and maturation of neurons, in development of the central nervous system. Noggin is also essential for skeletogenesis and bone joint formation and in development of heart
Anti-Noggin recognizes human noggin.
Anti-Noggin recognizes human noggin.
Immunogen
synthetic peptide corresponding to an internal sequence of human Noggin. This sequence is identical in rat and mouse.
Application
Anti-Noggin antibody is suitable for immunoblotting at a recommended working dilution of 1:1000 to 1:2000.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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P J Scotting et al.
Neuropathology and applied neurobiology, 22(6), 469-481 (1996-12-01)
In studies of the central nervous system (CNS) few areas have progressed faster than the study of transcription factors and their role in controlling gene expression during development. Evidence for the pivotal roles of these factors in the formation of
Identification of Mammalian Nervous System Noggin and Its Expression in the Adult
David M et al
The Journal of Neuroscience, 75, 6077-6084 (1995)
Y Gong et al.
Nature genetics, 21(3), 302-304 (1999-03-18)
The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members of the transforming growth factor beta superfamily of signalling proteins (TGFbeta-FMs), such as BMP4 (ref. 1). By diffusing through extracellular matrices more efficiently than TGFbeta-FMs, noggin may
Alexandra Klaus et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(27), 10921-10926 (2012-06-20)
Progenitor cells of the first and second heart fields depend on cardiac-specific transcription factors for their differentiation. Using conditional mutagenesis of mouse embryos, we define the hierarchy of signaling events that controls the expression of cardiac-specific transcription factors during differentiation
J Marcelino et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(20), 11353-11358 (2001-09-20)
Secreted noggin protein regulates bone morphogenetic protein activity during development. In mice, a complete loss of noggin protein leads to multiple malformations including joint fusion, whereas mice heterozygous for Nog loss-of-function mutations are normal. In humans, heterozygous NOG missense mutations
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