Netrin-4 (NTN4) is also called β−netrin and is expressed in the cortex. It is a 628 amino-acid protein.
Specificity
This antibody shows no cross-reactivity with rmNetrin-1, rhNetrin-1, rhNetrin-2, or rmNetrin-G1a.
Immunogen
purified, NS0-derived, recombinant human Netrin-4.
Biochem/physiol Actions
Netrin-4 (NTN4) associates with unc-5 homolog B (Unc5B). It has crucial roles in angiogenesis and axon branching.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
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Proceedings of the National Academy of Sciences of the United States of America, 111(42), 15226-15231 (2014-10-08)
Axon branching is remodeled by sensory-evoked and spontaneous neuronal activity. However, the underlying molecular mechanism is largely unknown. Here, we demonstrate that the netrin family member netrin-4 (NTN4) contributes to activity-dependent thalamocortical (TC) axon branching. In the postnatal developmental stages
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