N3787
Monoclonal Anti-Netrin-1 antibody produced in mouse
clone 158936, purified immunoglobulin, lyophilized powder
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About This Item
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
158936, monoclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
western blot: 1-2 μg/mL using rmNetrin-1
isotype
IgG2a
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Ntn1(18208)
General description
Netrin-1 (NTN1) is a secreted protein.[1]
Specificity
This antibody shows 100% cross-reactivity with rchNetrin-1 and no cross-reactivity with rhNetrin-2, rhNetrin-4, rmNetrin-4, or rmNetrin-G1a.
Immunogen
purified, NS0-derived, recombinant mouse Netrin-1.
Biochem/physiol Actions
Netrin-1 (NTN1) acts as a cardioprotectant. It can stimulate neovascularization of the retina in retinopathy. NTN1 has roles in angiogenesis and thymocyte adhesion.[1]
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Legal Information
This product or the use of this product is covered by U.S. Patents owned by The Regents of the University of California. This product is for research use only and is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for such purposes, contact The Regents of the University of California. Patent numbers 5,565,331; 6,096,866; 6,017,714; 6,309,638; and 6,670,451.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Xiao-Kai Guo et al.
Clinical & developmental immunology, 2013, 462152-462152 (2013-12-27)
Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still
Qiang Li et al.
American journal of physiology. Cell physiology, 309(2), C100-C106 (2015-05-01)
We have shown that netrin-1 induces potent cardioprotection via extracellular signal-regulated kinases 1 and 2 (ERK1/2)-dependent endothelial nitric oxide synthase (eNOS)/NO activation. The present study investigated cardioprotective effects of small netrin-1-derived peptides. We synthesized three laminin (Lam) V peptides and
Dan Liu et al.
BMC ophthalmology, 14, 102-102 (2014-08-26)
Netrin-1 has been reported to promote retinal neovascularization in oxygen-induced retinopathy (OIR). However, netrin-1 receptors, which may mediate netrin-1 action during retinal neovascularization, have not been characterized. In this study, we investigated netrin-1 receptor subtype expression and associated changes in
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