Nuclear factor κB (NF-κB) is a transcription factor that regulates a wide range of functions such as cell growth, angiogenesis, immunological responses and cell death. This protein has also been implicated in inflammation and carcinogenesis. Overexpression of NF-κB has been associated with breast and esophageal cancer . Monoclonal Anti-NAK antibody is specific for human, rat and chicken NAK.
Immunogen
human NAK fused to GST.
Application
Monoclonal Anti-NAK (NFκB-Activating Kinase) antibody can be used for western blot (1:250) and immunohistochemistry (1:50) assays in human mucosal tissues . The antibody is also suitable for use in indirect ELISA and microarrays.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Nuclear factor kappaB (NF-kappaB), a transcription factor, plays an important role in carcinogenesis as well as in the regulation of immune and inflammatory responses. NF-kappaB induces the expression of diverse target genes that promote cell proliferation, regulate apoptosis, facilitate angiogenesis
The Journal of surgical research, 123(1), 158-169 (2005-01-18)
The nuclear factor kappaB (NFkappaB) superfamily of eukaryotic transcription factors plays an important role in carcinogenesis. NF-kappaB and its regulators are linked to various signal transduction pathways as well as transcriptional activation events that mediate critical stages of cell proliferation.
To identify the molecular background of esophageal cancer, we conducted a proteomics study using an antibody microarray consisting of 725 antibodies and surgical specimens from three cases. The microarray analysis identified 24 proteins with aberrant expression in esophageal cancer compared
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