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COO/COA

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N2034

CR 2249

Name: CR 2249
Brand: SIGMA

Synonym(s):

(S)-4-Amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxopentanoic acid, Nebostinel

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₂₄N₂O₃

CAS Number:

163000-63-3

Molecular Weight:

256.34

MDL number:

MFCD00932765

UNSPSC Code:

12352200

PubChem Substance ID:

329818594

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SMILES string

CC1(C)CCC(CC1)NC(=O)[C@@H](N)CCC(O)=O

InChI

1S/C13H24N2O3/c1-13(2)7-5-9(6-8-13)15-12(18)10(14)3-4-11(16)17/h9-10H,3-8,14H2,1-2H3,(H,15,18)(H,16,17)/t10-/m0/s1

InChI key

VCRGLZYPNNAVRP-JTQLQIEISA-N

Gene Information

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444)

Biochem/physiol Actions

Facilitates glycine action at NMDA glutamate receptors; may identify a separate allosteric modulatory site on the NMDA receptor; putative cognition enhancer.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

050K4702

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Activity of putative cognition enhancers in kynurenate test performed with human neocortex slices.

A Pittaluga et al.

The Journal of pharmacology and experimental therapeutics, 290(1), 423-428 (1999-06-25)

Some cognition enhancers were previously shown to potently prevent antagonism of the N-methyl-D-aspartate (NMDA)-evoked release of norepinephrine (NE) brought about in slices of rat hippocampus by kynurenic acid, an endogenous NMDA receptor blocker. We have examined the impact of putative

Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex.

M Lanza et al.

Neuropharmacology, 36(8), 1057-1064 (1997-08-01)

The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-mediated reversion of kynurenate antagonism at

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