Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) is an atrial (ANP) and brain (BNP) natriuretic peptide receptor. NPR1 is a membrane-bound guanylate cyclase found predominantly in the kidneys that when activated by ANP or BNP promotes the process of sodium excretion, natriuresis.
Specificity
Rabbit polyclonal anti-NPR1 (436-448) antibody reacts with human natriuretic peptide receptor A.
Immunogen
synthetic peptide corresponding to amino acids 436-448 of human NPR1.
Biochem/physiol Actions
Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) is a marker gene implicated in nephropathy and hypertension phenotype. Polymorphic variant of NPR1 is associated with high risk for cardiac hypertrophy.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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A locus for an autosomal dominant form of progressive renal failure and hypertension at chromosome 1q21
Cohn DH, et al.
American Journal of Human Genetics, 67(3), 647-651 (2000)
Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects
Knowles JW, et al.
Human Genetics, 112(1), 62-70 (2003)
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