Recommended Products
biological source
human
recombinant
expressed in Pichia pastoris
form
dry powder
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CYP19A1(1588)
Biochem/physiol Actions
Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.
Features and Benefits
CypExpress 19A1 also know as Aromatase is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 19A1 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems.It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.
Legal Information
CypExpress is a trademark of Oxford Biomedical Research
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
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Aromatase deficiency: rare cause of virilization.
Barbara Ludwikowski et al.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 23(5), 418-422 (2012-10-25)
S C Janicki et al.
Dementia and geriatric cognitive disorders, 35(5-6), 340-346 (2013-05-03)
Few studies of gene variants that affect estrogen activity investigate their association with risk for Alzheimer's disease (AD) in women of different ethnicities. We investigated the influence of CYP19 polymorphisms on risk for AD in a multiethnic cohort of women
Asli Sezgin Caglar et al.
Endocrine, 49(3), 761-768 (2015-02-24)
The aim of this study is to evaluate aromatase expression in prolactin (PRL), thyroid stimulating hormone (TSH), and growth hormone (GH) secreting cells. Nontumoral human pituitary specimens were obtained from autopsy samples. Aromatase co-expression was determined by double immunohistochemical staining
Yong Joo Park et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 87, 157-165 (2015-12-27)
Ginkgo biloba has been used in herbal medicines for thousands of years. Although a standard G. biloba extract, EGb 761 has been used to improve cognition in breast cancer patients, its effects on breast cancer are unknown. Therefore, we investigated
Hong Zhao et al.
Journal of molecular endocrinology, 57(1), R19-R33 (2016-04-14)
Long-term exposure to excess estrogen increases the risk of breast cancer and type 1 endometrial cancer. Most of the estrogen in premenopausal women is synthesized by the ovaries, while extraovarian subcutaneous adipose tissue is the predominant tissue source of estrogen
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