MAK346
Activated Protein C (APC) Inhibitor Screening Kit
sufficient for 100 colorimetric tests
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About This Item
UNSPSC Code:
12352200
Recommended Products
usage
sufficient for 100 colorimetric tests
detection method
colorimetric
relevant disease(s)
hematological disorder
General description
Activated protein C (APC), a Vitamin K dependent serine protease, is formed by activation of Protein C by Thrombomodulin bound on the surface of endothelial cells. By degrading coagulation factors Va and VIIIa, APC inhibits blood coagulation which helps in the prevention of thrombosis. Blood coagulation can be stimulated by inhibition of APC. Thus, APC inhibitors play an important role in the treatment of disease like Haemophilia.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for screening and characterizing inhibitors/ligands of APC
Principle
The Activated Proctein C (APC) Inhibitor Screening Kit can be used to screen for potent inhibitors of APC activity. It utilizes the proteolytic activity of an active APC on a peptide substrate which releases a colored product. The released product can be easily quantified using an absorbance microplate reader. In the presence of an APC inhibitor, the enzyme decreases/loses activity resulting in lower/no absorbance.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
188.6 °F
flash_point_c
87 °C
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