MAK291
MMP-3 Activity Fluorometric Assay Kit
sufficient for 100 fluorometric tests
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.84
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detection method
fluorometric
relevant disease(s)
cancer
storage temp.
−20°C
General description
The matrix metalloproteinase-3 (MMP-3, stromelysin-1) exhibits a number of activities that would make it a particularly good tumor promoter. Like several other MMPs, MMP-3 was first cloned and later recloned as a cancer-specific gene. In addition to degrading numerous extracellular matrix components, MMP-3 can activate gelatinase B, the collagenases and several serpin-type serine proteinase inhibitors. Moreover, it can release a number of cell surface molecules, including E-cadherin, a known contributor to cancer development.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for measuring MMP-3 activity in various biological samples.
Principle
Matrix metalloproteinase-3 (MMP-3) assay kit, MMP-3 hydrolyzes a specific FRET (fluorescence resonance energy transfer) substrate to release the quenched fluorescent group Mca, which can be detected fluorometrically (lex = 325 nm/lem = 393 nm). The kit provides a rapid, simple, sensitive and reliable test, which can also be used as a high throughput assay of MMP-3 activity. The assay sensitivity is <50 mU.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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