MAK258

Hepatic Steatosis Assay Kit

sufficient for 100 colorimetric or fluorometric tests

• UNSPSC Code: 12352200
• NACRES: NA.84

Properties

• application(s): pharmaceutical
• detection method: colorimetric; fluorometric
• relevant disease(s): gastrointestinal diseases
• storage temp.: −20°C

Description

General description

Hepatic Steatosis, also known as fatty liver, is a disease characterized by an excessive accumulation of lipid droplets within the liver. This can be caused by multiple factors, including excessive alcohol intake, obesity, and other diseases with abnormal fat metabolism. Hepatic Steatosis is commonly used as a marker to determine the hepatotoxicity of drug candidates.

Suitability

Evaluate hepatic steatosis, quantify triglycerides, and visualize lipid droplet accumulation in hepatocytes. As well as screen drug candidates for steatotic risk.

Principle

The Hepatic Steatosis Kit detects triglyceride accumulation and lipid droplet formation in hepatocytes. The kit can be used to screen and evaluate steatosis risk of drug candidates and to study the mechanism of steatosis development. Chloroquine is included as a positive control for inducing steatosis in liver cells, such as HepG2.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H317,H319,H331,H334,H335,H341,H350
• pcodes: P280 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects