MAK245
Plasmin Inhibitor Screening Kit (Fluorometric)
sufficient for 100 fluorometric tests
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352200
NACRES:
NA.25
Recommended Products
detection method
fluorometric
relevant disease(s)
cancer; hematological disorder
storage temp.
−20°C
General description
Plasmin (EC 3.4.21.7) is a serine protease occurring in plasma as plasminogen. Upon activation via cleavage by plasminogen activators; plasmin solubilizes fibrin clots and activates and/or degrades compounds of the coagulation and complement systems. Plasmin inhibitors are critical in the treatment of hyperfibrinolysis-associated with blood loss and other related complications. A number of biological processes including immune response, fibrinolysis, hemostasis and the elimination of inflammation are affected by serine protease inhibition. Snake venom is considered to be a source of many serine protease inhibitor.[1]
Suitability
Suitable for screening potential inhibitors of plasmin and characterizing/studying plasmin inhibitors in plasma samples.
Principle
The Plasmin Inhibitor Screening Kit utilizes the ability of plasmin to cleave a synthetic AMC-based peptide substrate and release a fluorophore, AMC, which can be easily quantified by fluorescence microplate readers. In the presence of plasmin specific inhibitors, the extent of cleavage reaction is reduced or completely abolished. The loss in the fluorescence intensity can be correlated to the amount of inhibitor present in the assay solution. The kit provides a simple and rapid method to screen potential inhibitors of Plasmin.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor.
Choo Y M, et al.
PLoS ONE, 7(2), e32269-e32269 (2012)
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
