The Factor Xa enzyme in product MAK239 is sourced from bovine.
MAK239
Factor Xa Inhibitor Screening Kit (Fluorometric)
sufficient for 100 fluorometric tests
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.25
Recommended Products
detection method
fluorometric
relevant disease(s)
hematological disorder
storage temp.
−20°C
General description
Factor Xa (FXa) is also known as Stuart-Power factor, thrombokinase, prothrombinase and thromboplastin. The protein′s EC number is E.C.3.4.21.6. Factor Xa is the activated form of the coagulation factor X. Factor X is a vitamin K-dependent serine endopeptidase plays an important role at several stages of the coagulation pathway. It is produced in the liver and in the plasma, it circulates as a two-chain glycoprotein. Factor X acts by converting prothrombin into active thrombin by complexing with activated co-factor V in the prothrombinase complex.[1] Unfractionated heparin and various low molecular weight heparins bind to plasma cofactor antithrombin to inactivate several coagulation factors including factor Xa.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for Screening potential inhibitors of Factor Xa and characterizing/studying Factor Xa inhibitors in plasma samples.
Principle
Factor Xa Inhibitor Screening Kit (Fluorometric) utilizes the ability of factor Xa to cleave a synthetic substrate, thereby releasing a fluorophore, 7-amino-4-methylcoumarin (AMC), which can be quantified by a fluorescence reader. In the presence of an inhibitor, the extent of the cleavage reaction is reduced or completely abolished. The loss in the fluorescence intensity can be correlated to the amount of inhibitor present in the assay solution. The factor Xa Inhibitor Screening Kit is a simple, straightforward, high throughput assay to screen factor Xa inhibitors.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Structure and dynamics of zymogen human blood coagulation factor X.
Venkateswarlu D, et al.
Biophysical Journal, 82(3), 1190-1206 (2002)
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Which species is the Factor Xa enzyme derived from in this assay?
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