MAK237
Beta-Secretase Activity Fluorometric Assay Kit
sufficient for 100 fluorometric tests
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.84
Recommended Products
detection method
fluorometric
relevant disease(s)
neurological disorders
storage temp.
−70°C
General description
β-Secretase has been implicated to be an excellent target for anti-amyloid therapy for the treatment of Alzheimer′s disease.
Suitability
Suitable for the determination of ß-Secretase activity in biological and purified samples.
Principle
The β-Secretase activity Assay Kit provides a convenient fluorescence method for detecting β-secretase activity in biological and purified samples. The assay utilizes a secretase-specific peptide conjugated to two reporter molecules EDANS and DABCYL. In the uncleaved form, the fluorescent emissions from EDANS are quenched by the physical proximity of the DABCYL moiety. Cleavage of the peptide by secretase physically separates EDANS and DABCYL allowing for the release of a fluorescent signal. The level of secretase enzymatic activity in samples is proportional to the level of fluorescence intensity.
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Description
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hcodes
pcodes
Hazard Classifications
Aquatic Chronic 2
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice.
Youngsoo Oh et al.
International journal of molecular sciences, 23(18) (2022-09-24)
Alzheimer's disease (AD), a common form of dementia, is caused in part by the aggregation and accumulation in the brain of amyloid β (Aβ), a product of the proteolytic cleavage of amyloid precursor protein (APP) in endosomes. Trafficking of APP
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