MAK209
Granzyme B Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
GZMB Inhibitor Screening Kit
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About This Item
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detection method
fluorometric
relevant disease(s)
immunological diseases; orthopedic diseases; cardiovascular diseases; rheumatological diseases
storage temp.
−20°C
Gene Information
human ... GZMB(3002)
mouse ... GZMB(14939)
rat ... GZMB(171528)
General description
Granzyme B (GZMB; EC 3.4.21.79) is a serine protease stored in the secretory granules of leukocytes. It induces cytotoxic T lymphocyte (CTL)-mediated apoptosis by the activation of caspases and the degradation of structural proteins of the target cells. Granzyme B has an important role in CTL-mediated immune responses and has been implicated in chronic inflammatory diseases such as rheumatoid arthritis, coronary syndrome, and chronic angina pectoris.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for the screening of inhibitors of Granzyme B.
Principle
The Granzyme B Inhibitor Screening Kit is a simple and high-throughput assay for screening potential inhibitors of granzyme B. Granzyme B activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 380/ λem = 500 nm), proportional to the enzymatic activity present. The substrate includes the recognition sequence for granzyme B.
Kit Components Only
Product No.
Description
- Granzyme B Assay Buffer
- Granzyme B Substrate
- Granzyme B Enzyme
- Inhibitor Control, Ac-IEPD-CHO
Storage Class
10 - Combustible liquids
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