MAK201
Cathepsin K Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
CTSK Inhibitor Screening Kit, Cathepsin K Inhibitor Assay Kit
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.25
Recommended Products
detection method
fluorometric
relevant disease(s)
orthopedic diseases; aging/geriatric diseases
shipped in
dry ice
Storage temp.
−70°C
Gene Information
human ... CTSK(1513)
mouse ... CTSK(13038)
rat ... CTSK(29175)
General description
Cathepsin K (CTSK; EC 3.4.22.38) is a lysosomal cysteine proteinase expressed predominantly in the osteoclasts. It exhibits potent collagenase activity and is involved in bone remodeling and resorption. Mutations in CTSK gene result in pycnodysostosis characterized by osteosclerosis and short stature.
Suitability
Suitable for the screening of inhibitors of Cathepsin K.
Principle
The Cathepsin K Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSK. CTSK activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/ λem = 505 nm), proportional to the enzymatic activity present.
Kit Components Only
Product No.
Description
- CTSK Reaction Buffer
- CTSK Reagent
- Cathepsin K, human
- CTSK Substrate, Ac-LR-AFC, 10 mM
- CTSK Inhibitor, F-F-FMK, 1 mM
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
10 - Combustible liquids
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