M9948

Mirin

≥98% (HPLC), powder

• Synonym(s): 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
• Empirical Formula (Hill Notation): C₁₀H₈N₂O₂S
• CAS Number: 299953-00-7
• Molecular Weight: 220.25
• MDL number: MFCD05885480
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818100
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: red to orange
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
• InChI: 1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
• InChI key: YBHQCJILTOVLHD-YVMONPNESA-N
• Gene Information: human ... MRE11A(4361)

Description

Application

Mirin has been used:

• as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
• as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
• in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Biochem/physiol Actions

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable