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Key Documents

M9189

Sigma-Aldrich

1-N-Methylamino-3,5-dimethyladamantane hydrochloride

>98% (HPLC), solid

Synonym(s):

MD-Ada hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H23N · HCl
Molecular Weight:
229.79
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

assay

>98% (HPLC)

form

solid

color

white

solubility

H2O: 16 mg/mL

SMILES string

Cl.CNC12CC3C[C@@](C)(C[C@@](C)(C3)C1)C2

InChI

1S/C13H23N.ClH/c1-11-4-10-5-12(2,7-11)9-13(6-10,8-11)14-3;/h10,14H,4-9H2,1-3H3;1H/t10-,11+,12-,13-;

InChI key

MZAJFEVHLOKXJM-CXAAXDCWSA-N

Biochem/physiol Actions

Antagonist of the NMDA receptor-channel complex. Abolishes the PrionSc-induced neuronal injury in vitro, and displays no influence on the synthesis and/or the processing of PrionSc

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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W E Müller et al.
European journal of pharmacology, 246(3), 261-267 (1993-08-15)
Rat cortical cells were incubated with the Scrapie prion protein, PrionSc. At concentrations of 3 ng/ml of PrionSc and higher, the viability of the cells decreased significantly after a 12-h incubation period. Simultaneously, the degree of DNA fragmentation increased. In

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