Major vault protein (MVP) is also called lung resistance protein (LRP). It forms the outer shell of vaults (ribonucleoprotein particles present in the cytoplasm).
Specificity
Reacts with an internal epitope of LRP/MVP (P110).
Immunogen
drug resistant tumor cell line SW-1573/2R120.
Biochem/physiol Actions
Major vault protein (MVP) mediates responses of cells to stress and might play a role in multidrug resistance. It has been shown to be overexpressed in drug-resistant cancer cells.
Physical form
Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Despite their ubiquitous expression and high conservation during evolution, precise cellular functions of vault ribonucleoparticles, mainly built of multiple major vault protein (MVP) copies, are still enigmatic. With regard to cancer, vaults were shown to be upregulated during drug resistance
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