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M6942

Sigma-Aldrich

Monoclonal Anti-Minor Vault Protein 193 antibody produced in mouse

250 μg/mL, clone p193-10, tissue culture supernatant

Synonym(s):

Anti-VPARP, Anti-p193

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

p193-10, monoclonal

species reactivity

human

concentration

250 μg/mL

technique(s)

immunocytochemistry: 1:10-1:20 using 4% paraformaldehyde-fixed cytospin preparations
immunohistochemistry (frozen sections): 1:10-1:20
western blot (chemiluminescent): 1:10-1:20

isotype

IgG2aκ

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PARP4(143)

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General description

Minor vault protein 193 is also known as poly (ADP-ribose) polymerase family member 4 (PARP4). Along with two other proteins, it is part of vaults (ribonucleoprotein particles present in the cytoplasm). The molecular weight of this protein is 193kDa.

Specificity

Reacts with an internal epitope (aa 506-510, VALGK) of p193.

Immunogen

E. coli lysate transformed with the pET28a(+) expression vector containing amino acids 408-611 of the p193 cDNA.

Biochem/physiol Actions

Minor vault protein 193 is highly expressed in tumors.

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albulin and 0.1% sodium azide.

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Storage Class

10 - Combustible liquids


Certificates of Analysis (COA)

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Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer.
Szaflarski W
International Journal of Oncology, 43(2), 513-520 (2013)
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.
Kickhoefer VA
The Journal of Cell Biology, 146(5), 917-928 (1999)

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