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M6792

Sigma-Aldrich

Anti-Macrophage Inflammatory Protein-1β antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-MIP-1β

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About This Item

MDL number:
MFCD00213008
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable

UniProt accession no.

P13236

storage temp.

−20°C

Gene Information

human ... CCL4(6351)

General description

The antibody will neutralize the biological activity of recombinant human, but not mouse MIP-1β. It will not neutralize the biological activity of recombinant human or mouse MIP-1α.

Immunogen

recombinant human MIP-1β, expressed in Sf 21 insect cells.

Biochem/physiol Actions

Macrophage inflammatory protein-1β (CCL4) belongs to a family of MIP-1 chemotactic cytokines (CC). The members of MIP-1 family have the ability to self-associate and form aggregates of high molecular weight. The self- aggregation is a reversible process and occurs in T cells, B cells and macrophages in response to inflammatory factors and bacterial endotoxins. This response results in inflammation and platelet degranulation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
074H0539

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M D Miller et al.
Critical reviews in immunology, 12(1-2), 17-46 (1992-01-01)
Studies conducted in many laboratories over the past several years have resulted in the identification and initial characterization of a large superfamily of structurally and functionally related inflammatory cytokines. This superfamily currently includes 14 distinct members: platelet factor 4, beta-thromboglobulin
M Maurer et al.
The international journal of biochemistry & cell biology, 36(10), 1882-1886 (2004-06-19)
Macrophage inflammatory protein (MIP)-1alpha was identified 15 years ago as the first of now four members of the MIP-1 CC chemokine subfamily. These proteins termed CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL9/10 (MIP-1delta), and CCL15 (MIP-1gamma) according to the revised nomenclature for
L G Czaplewski et al.
The Journal of biological chemistry, 274(23), 16077-16084 (1999-05-29)
Human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation normal T cell expressed) self-associate to form high-molecular mass aggregates. To explore the biological significance of chemokine aggregation, nonaggregating variants were sought. The phenotypes of 105 hMIP-1alpha

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