M6567

Monoclonal Anti-MRP3 antibody produced in mouse

250 μg/mL, clone M₃II-21, tissue culture supernatant

• Synonym(s): Anti-Multidrug Resistance Associated Protein 3
• MDL number: MFCD02263753
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: tissue culture supernatant
• antibody product type: primary antibodies
• clone: M₃II-21, monoclonal
• mol wt: antigen 190-200 kDa
• species reactivity: human
• concentration: 250 μg/mL
• technique(s): immunocytochemistry: 1:20-1:50 using acetone- or formaldehyde-fixed cytospin preparations; immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections; western blot: 1:20-1:50
• isotype: IgG1
• UniProt accession no.: O15438
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... ABCC3(8714)

Description

General description

Multidrug Resistance-Associated Protein (MRP) is a seven member subfamily of ABC (ATP-binding cassette) transporters. MRP1, 2, and 3 have a similar structure with the ability to transport glutathione and glucuronate conjugates. MRP4 and MRP5 share more structure similarity with each other than with MRP1, 2, and 3. MRP4 and MRP5 also have the ability to transport cyclic nucleotides..The monoclonal anti-MRP3 recognizes human Multidrug Resistance-Associated Protein 3 (MRP3, 190-200 kDA)..

Specificity

Reacts with an internal epitope of MRP3. Does not cross-react with the human MDR1, MRP1, MRP2, or MRP5 gene products.

Immunogen

fusion protein of MRP3 (amino acids 830-949).

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

The antibody may be used in immunocytochemistry, immunoblotting, immunohistochemistry.

Physical form

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Preparation Note

Monoclonal Anti-Multidrug Resistance-Associated Protein 3 (MRP3), mouse isotype IgG1, derived using M₃II-21 hybridoma produced by fusion SP2/O mouse myeloma cells and Balb/c mouse lymph nodes cells immunized with amino acids 830-949 of the human MRP3 bacterial fusion protein. The antibody is concentrated from culture supernatant of M₃II-21 hybridoma cells grown in a bioreactor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids