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M6315

Monoclonal Anti-Mismatch Repair Protein 2 antibody produced in mouse

Name: Monoclonal Anti-Mismatch Repair Protein 2 antibody produced in mouse
Brand: SIGMA

~1 mg/mL, clone 2MSH01, tissue culture supernatant

Synonym(s):

Anti-MSH2

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About This Item

MDL number:

MFCD00282379

UNSPSC Code:

12352203

NACRES:

NA.41

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

2MSH01, monoclonal

mol wt

antigen 102 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25

isotype

IgG1

UniProt accession no.

P43246

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MSH2(4436)

General description

Mismatch repair protein 2 (MSH2) possesses four domains and belongs to the mismatch repair (MMR) gene family. The gene encoding this protein is localized on human chromosome 2p21.

Immunogen

recombinant human mismatch repair protein 2 (MSH2).

Biochem/physiol Actions

Mismatch repair protein 2 (MSH2) plays a very important role in the DNA mismatch repair system. It repairs DNA damage which is induced by drugs. MSH2 dysfunction has been associated with nonpolyposis colorectal cancer (Lynch syndrome).

Physical form

Contains 15 mM sodium azide.

Storage Class

10 - Combustible liquids

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Certificates of Analysis (COA)

Lot/Batch Number

042K1261

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Characterization of complementary determinant region 3δ in human MutS homologue 2-specific γδ T cells.

H Chen et al.

Scandinavian journal of immunology, 81(2), 121-128 (2014-11-21)

γδT cells function as sentinels in early host responses to infections and malignancies. Previously, we found ectopically expressed human MutS homologue 2 (hMSH2), recognized by γδT cells, triggered a γδT cell-mediated cytolysis to tumor cells. However, the characteristics of hMSH2-specific

hMSH2 expression is associated with paclitaxel resistance in ovarian carcinoma, and inhibition of hMSH2 expression in vitro restores paclitaxel sensitivity.

Jin Zhang et al.

Oncology reports, 32(5), 2199-2206 (2014-09-02)

The objective of the present study was to investigate the association between paclitaxel resistance, gene copy number, and gene expression in ovarian carcinoma, and to restore paclitaxel sensitivity in a paclitaxel-resistant ovarian carcinoma cell line by using hMSH2-targeting siRNA. Paclitaxel-resistant

Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells.

Jen-Chung Ko et al.

Biochemical and biophysical research communications, 456(1), 506-512 (2014-12-10)

The anti-estrogen tamoxifen has been used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been identified. Human MutS homolog

Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

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