Multidrug resistance associated protein 5 (MRP5) is a short type organic anion pump which belongs to the ATP-binding cassette transporter superfamily.
Specificity
Reacts with an internal epitope of MRP5. Does not cross-react with the human MDR1, MRP1, MRP2, MRP3 gene products.
Immunogen
human MRP5 (amino acids 82-168) bacterial fusion protein.
Biochem/physiol Actions
Multidrug resistance associated protein 5 (MRP5) is involved in pumping out cyclic guanosine monophosphate (cGMP) from the cell. It can also export anti-viral and anti-cancer drugs. MRP5 has been shown to be overexpressed in breast cancer.
Physical form
Supplied in serum-free culture medium containing 0.7% bovine serum albulin and 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Breast cancer research : BCR, 14(6), R149-R149 (2012-11-24)
Bone is the most common site of breast cancer metastasis, and complications associated with bone metastases can lead to a significantly decreased patient quality of life. Thus, it is essential to gain a better understanding of the molecular mechanisms that
The ABCC5 gene encodes an organic anion pump of the ATP-binding cassette (ABC) transporter family, subclass C. The exact physiological function of ABCC5 however is not known. Here, we have isolated three novel ABCC5 splice variants and characterized their role
Pharmacogenetics and genomics, 15(2), 91-104 (2005-04-30)
The ABCC5 transporter is a ubiquitously expressed ATP-dependent efflux pump that exports nucleotide analogues, including thiopurine anticancer drugs and antiviral drugs. Polymorphisms within this gene may be associated with differences in response to these drugs between different individuals. Haplotype mapping
Annals of human genetics, 78(5), 333-344 (2014-08-15)
Numerous functional studies have implicated PARL in relation to type 2 diabetes (T2D). We hypothesised that conflicting human association studies may be due to neighbouring causal variants being in linkage disequilibrium (LD) with PARL. We conducted a comprehensive candidate gene
Carcinoma of the uterine cervix represents the second most frequent female malignancy worldwide, but few biochemical tumour markers have been implemented into clinical practice. Elevated extracellular guanosine 3', 5'-cyclic monophosphate (cGMP) levels have been reported to be a sensitive, early
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