Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on human chromosome 11.
Specificity
The antibody recognizes only the latent form of MMP-12 and not the active forms. May be used to distinguish the zymogen and the activated enzyme.
Immunogen
synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-12 (macrophage elastase).
Biochem/physiol Actions
Matrix metalloproteinase-12 (MMP-12) is involved in breaking down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.
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Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect
Aortic dissection(AD) is an acute process of large blood vessels characterized by dangerous pathogenic conditions and high disability and high mortality. The pathogenesis of AD remains debated. Matrix metalloproteinase-12 (MMP-12) participates in many pathological processes such as abdominal aortic aneurysm
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