M6053

Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-MMP-3
• MDL number: MFCD03455413
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen 59 kDa; antigen (pro-form) 57 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): western blot: 1:1000
• UniProt accession no.: P08254
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MMP3(4314)

Description

General description

Matrix metalloproteinase-3 (MMP-3) is also known as stromelysin 1 and the gene encoding it is localized on human chromosome 11q22.3.

Specificity

Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.

Immunogen

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).

Biochem/physiol Actions

Matrix metalloproteinase-3 (MMP-3) plays an important role in cartilage degradation. It can act on a large number of substrates like type II, III, IV, IX and X collagens, laminin and fibronectin. MMP-3 can also activate other matrix metalloproteinases like MMP-1,-2 and -13. It has been associated with rheumatoid arthritis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids