M6034
IgG2a, Lambda from murine myeloma
clone HOPC-1, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Mouse IgG2a-λ
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1 MG
$252.08
About This Item
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
HOPC-1, monoclonal
form
buffered aqueous solution
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
An immunoglobulin has two heavy chain and two light chain connected by disulfide bond.[1] It is a glycoprotein. Rat has five immunoglobulin classes- IgM, IgG, IgA, IgD and IgGE.[2] Immunoglobulin G (IgG) is a major class of immunoglobulin. IgG has four subclasses- IgG1, IgG2a, IgG2b and IgG2c.[3]
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections[4]
IgG2a, λ from murine myeloma specifically recognizes mouse IgG2a. Specificity of the mouse IgG2a, λ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgG1, IgG2a, IgG2b and IgG3.
IgG2a, λ from murine myeloma specifically recognizes mouse IgG2a. Specificity of the mouse IgG2a, λ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgG1, IgG2a, IgG2b and IgG3.
Application
IgG2a, Lambda from murine myeloma has been used to standardize the enzyme-linked immunosorbent assay (ELISA) assay.[5]
Biochem/physiol Actions
Physical form
Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Molecular Genetics of Immunoglobulin, 17 (1987)
The Immunoglobulins: Structure and Function (1998)
The Laboratory Rat (1998)
M Motta et al.
Leukemia, 19(10), 1788-1793 (2005-08-12)
Patients with chronic lymphocytic leukemia (CLL) have defects in both cellular and humoral immunity. Since CD152 (CTLA-4) plays a critical role in downregulating T-cell responses, we studied the expression of surface and cytoplasmic CD152 (sCD152 and cCD152, respectively) in freshly
A V Popov et al.
The Journal of experimental medicine, 189(10), 1611-1620 (1999-05-20)
Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) lambda light (L) chain locus in germline configuration were created. The introduced translocus on a yeast artificial chromosome (YAC) accommodates the most proximal Iglambda variable region (V) gene cluster
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