M5917
Anti-Macrophage Inflammatory Protein-1β antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Synonym(s):
Anti-MIP-1β
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About This Item
biological source
goat
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
neutralization: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Ccl4(20303)
General description
Macrophage Inflammatory Protein-1-β is a member of the chemokine family and is produced in macrophages when stimulated by bacterial endotoxins. Anti-macrophage inflammatory protein-1β antibody can be used in immunoblotting. Goat anti-macrophage inflammatory protein-1β antibody reacts specifically with recombinant mouse MIP-1 β but does not react with recombinant human MIP-1 β or recombinant mouse or human MIP-1α.
Macrophage inflammatory protein-1 β (CCL4) belongs to a family of MIP-1 chemotactic cytokines (CC). The other members are CCL3 (MIP-1α), CCL9/10 (MIP-1δ) and CCL15 (MIP-1γ). The members of MIP-1 family have the ability to self-associate and form aggregates of high molecular weight. The self- aggregation is a reversible process and occurs in T cells, B cells and macrophages in response to inflammatory factors and bacterial endotoxins. This response results in inflammation and platelet degranulation
Anti-Macrophage Inflammatory Protein-1β antibody is specific for mouse MIP-1 β. It shows less than 2% cross reactivity with recombinant mouse MIP-1α, recombinant human MIP-1α and MIP-1β.
Anti-Macrophage Inflammatory Protein-1β antibody is specific for mouse MIP-1 β. It shows less than 2% cross reactivity with recombinant mouse MIP-1α, recombinant human MIP-1α and MIP-1β.
Immunogen
recombinant mouse MIP-1β expressed in E. coli.
Application
Anti-Macrophage Inflammatory Protein-1β antibody may be for immunoblotting at a working concentration of 1.0 μg/ml. The antibody is suitable for neutralization reactions.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, containing 5% trehalose
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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B Sherry et al.
The Journal of experimental medicine, 168(6), 2251-2259 (1988-12-01)
A number of macrophage-derived mediators have been implicated in the vascular changes of inflammation. We recently reported the isolation of a novel monokine, macrophage inflammatory protein 1 (MIP-1), which causes local inflammatory responses in vivo, and induces superoxide production by
M Maurer et al.
The international journal of biochemistry & cell biology, 36(10), 1882-1886 (2004-06-19)
Macrophage inflammatory protein (MIP)-1alpha was identified 15 years ago as the first of now four members of the MIP-1 CC chemokine subfamily. These proteins termed CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL9/10 (MIP-1delta), and CCL15 (MIP-1gamma) according to the revised nomenclature for
M D Miller et al.
Critical reviews in immunology, 12(1-2), 17-46 (1992-01-01)
Studies conducted in many laboratories over the past several years have resulted in the identification and initial characterization of a large superfamily of structurally and functionally related inflammatory cytokines. This superfamily currently includes 14 distinct members: platelet factor 4, beta-thromboglobulin
L G Czaplewski et al.
The Journal of biological chemistry, 274(23), 16077-16084 (1999-05-29)
Human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation normal T cell expressed) self-associate to form high-molecular mass aggregates. To explore the biological significance of chemokine aggregation, nonaggregating variants were sought. The phenotypes of 105 hMIP-1alpha
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