Matrix metalloproteinase-19 (MMP19) is a zinc-dependent endopeptidase. It contains a signal sequence, a propeptide domain, a catalytic domain and a carboxy-terminal fragment. The gene encoding this protein is located on human chromosome 12q14.
Specificity
Reacts with reduced and non-reduced MMP-19. Recognizes the pro-form of MMP-19. Binds the propeptide region, which is removed during activation. Can be used to distinguish between the pro-form and active forms of MMP-19.
Immunogen
synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-19 (RASI).
Biochem/physiol Actions
Matrix metalloproteinase-19 (MMP-19) may have a role in arthritis and takes part in the advancement of lung cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4 containing 50% glycerol and 15 mM sodium azide.
Matrix metalloproteinase (MMP)-19 and MMP-20 (enamelysin) are two recently discovered members of the MMP family. These enzymes are involved in the degradation of the various components of the extracellular matrix (ECM) during development, haemostasis and pathological conditions. Whereas MMP-19 mRNA
The Journal of biological chemistry, 275(20), 14809-14816 (2000-05-16)
We have recently cloned MMP-19, a novel matrix metalloproteinase, which, due to unique structural features, was proposed to represent the first member of a new MMP subfamily (Pendás, A. M., Knäuper, V. , Puente, X. S., Llano, E., Mattei, M.
American journal of respiratory and critical care medicine, 190(7), 780-790 (2014-09-25)
Lung cancer is the leading cause of cancer death in both men and women in the United States and worldwide. Matrix metalloproteinases (MMPs) have been implicated in the development and progression of lung cancer, but their role in the molecular
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