Matrix metalloproteinase-18 (MMP-18) is an interstitial collagenase which possesses a special insertion domain of 37 amino acids. It is made up of around 626 amino acids. During metamorphosis, MMP-18 is controlled in tissue-dependent way.
Specificity
Reacts with reduced and non-reduced MMP-18. Recognizes the pro-form and the active forms of MMP-18. By immunoblotting, the antibody reacts with bands at 53 kDa and 51 kDa (proform).
Immunogen
synthetic peptide corresponding to the N-terminal of Xenopus matrix metalloproteinase-18 (Xenopus collagenase, collagenase-4)
Biochem/physiol Actions
Matrix metalloproteinase-18 (MMP-18) plays an important role in the development of Xenopus laevis.
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide
Molecular biology of the cell, 7(10), 1471-1483 (1996-10-01)
Matrix metalloproteinases (MMPs) participate in extracellular matrix remodeling and degradation and have been implicated in playing important roles during organ development and pathological processes. Although it has been hypothesized for > 30 years that collagenase activities are responsible for collagen
The Journal of biological chemistry, 272(21), 13527-13533 (1997-05-23)
To study the role of matrix metalloproteinases (MMPs) in early vertebrate development, we cloned cDNAs for six different MMPs from the frog Xenopus laevis embryos at different stages of development and describe here a novel MMP called XMMP. Xenopus XMMP
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