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M4939

Sigma-Aldrich

Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse

≥97% (HPLC)

Synonym(s):

MOG Peptide 35-55 Rat, Mouse

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0.5 MG
$247.50
1 MG
$412.20

About This Item

CAS Number:
163913-87-9
MDL number:
MFCD02265607
UNSPSC Code:
12352209
NACRES:
NA.26

$247.50

List Price$275.00Save 10%
Web-Only Promotion

Available to ship onApril 29, 2025Details

Request a Bulk Order

Product Name

Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse, immunodominant epitope of MOG

Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

Q61885
Q63345

application(s)

cell analysis

storage temp.

−20°C

Gene Information

mouse ... Mog(17441)
rat ... Mog(24558)

Amino Acid Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys

General description

Myelin oligodendrocyte glycoprotein (MOG) is a component of the central nervous system and present on the surface of oligodendrocytes and myelin. Its extracellular domain is widely used to generate an autoimmune animal model of multiple sclerosis.[1] In rats, it is expressed in the hippocampus.[2]

Application


  • Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.: This paper investigates the delayed therapeutic administration of erythropoietin and its derivatives in the treatment of autoimmune encephalomyelitis, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce the disease model in mice (Savino et al., 2006).

  • Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE.: This research explores the role of serotonin reuptake in modulating immune responses and susceptibility to autoimmune diseases, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce experimental autoimmune encephalomyelitis in mice (Hofstetter et al., 2005).

  • Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.: The study demonstrates the effectiveness of trichostatin A, a histone deacetylase inhibitor, in treating experimental autoimmune encephalomyelitis. Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 was used to induce the disease model in rats and mice, providing insights into potential epigenetic therapies (Camelo et al., 2005).

Biochem/physiol Actions

Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000252819
0000233424
0000252820
0000142857
039M4879V

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Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption.
Okamoto H
Neuroscience Letters, 406(1-2), 76-80 (2006)
Ewa Balkowiec-Iskra et al.
Acta neurobiologiae experimentalis, 63(2), 109-115 (2003-08-21)
The pathological process of neurodegeneration is accompanied by an inflammatory reaction that is believed to contribute to the pathogenesis of neurodegenerative diseases. The aim of our study was to evaluate the influence of autoimmune reaction induced by post-traumatic vaccination with
Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice
Cecile Delarasse
Immunology, 140(4), 456-464 (2013)
Sajad Karampoor et al.
International immunopharmacology, 78, 105943-105943 (2019-12-13)
A growing body of evidence has shown that the human immunodeficiency virus (HIV) infection is associated with a significantly decreased risk of developing multiple sclerosis (MS) in patients with acquired immunodeficiency virus (AIDS). It is thought that two mechanisms are
Rong Chen et al.
Frontiers in molecular neuroscience, 13, 114-114 (2020-07-23)
Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS) that currently does not have any effective treatment. Experimental autoimmune encephalomyelitis (EAE) is often employed as a model to mimic the clinical manifestations of MS, mainly
View All Related Papers

Questions

1–7 of 7 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Can I combine this peptide (Product No. M4939) with an adjuvant to prepare an immunizing emulsion?

    1 answer

    1. Unfortunately, we have no data based on our own studies or on literature references on Product No. M4939 to answer this question.

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  4. What can I use to dissolve this peptide (Product No. M4939)?

    1 answer

    1. Every lot is tested for solubility at a concentration of 1 mg/mL, using either 1% acetic acid or water, resulting in a clear, colorless solution. The peptide is also soluble in an aqueous buffer such as 0.01 M PBS, pH 7.4, but we do not know whether it is equally as soluble in these buffers as it is in dilute acetic acid or water.

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  5. What is the difference between peptide content and purity of Product No. M4939?

    1 answer

    1. If a given lot of Product No. M4939 has, say, a peptide content of 85% and purity of 99%, this means that 85% of the vial content is the peptide, the remaining being water and trifluoroacetate salts. Of the 85% that is the peptide, 99% is Myelin oligodendroctye glycoprotein peptide fragment (35-55).

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  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  7. For how long is a solution of this peptide (Product No. M4939) stable?

    1 answer

    1. Sigma-Aldrich has not performed any solution stability studies on M4939, so we do not have information as to whether solutions are stable refrigerated or frozen.

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