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M4449

Sigma-Aldrich

Myelin Oligodendrocyte Glycoprotein (35-55), Human

lyophilized powder

Synonym(s):

MOG 35-55

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About This Item

Empirical Formula (Hill Notation):
C120H179N35O28S
CAS Number:
163158-19-8
Molecular Weight:
2591.99
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

assay

97-100% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: soluble

UniProt accession no.

Q16653

storage temp.

−20°C

Gene Information

human ... MOG(4340)

Amino Acid Sequence

H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Pro-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH

General description

MOG (myelin oligodendrocyte glycoprotein) is an integral membrane protein. It is expressed in the central nervous system and is localized to oligodendrocytes and myelin lamellae (outermost).[1] The MOG gene is mapped to human chromosome 6p22.1.[2]

Biochem/physiol Actions

MOG serves as an efficient CD4+ T-cell response inducer in vitro.[3] This protein consists of 218 amino acids and two transmembrane domains.[1]
This is a truncated peptide from the human Myelin Oligodendrocyte Glycoprotein (MOG) responsible for the induction of experimental autoimmune encephalomyelitis in mouse and rat models for human multiple sclerosis research.

Physical form

Lyophilized from 0.1% aqueous TFA.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
011M4776V
011M4775V

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Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis
Lalive PH, et al.
Proceedings of the National Academy of Sciences of the USA, 103, 2280?2285-2280?2285 (2005)
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
Haas J, et al.
The Journal of Biological Chemistry, 35, 3343-3352 (2005)
Li-Ting Wang et al.
Autophagy, 17(12), 4202-4217 (2021-04-16)
We propose that beyond its role in WNT secretion, WLS/GPR177 (wntless, WNT ligand secretion mediator) acts as an essential regulator controlling protein glycosylation, endoplasmic reticulum (ER) homeostasis, and dendritic cell (DC)-mediated immunity. WLS deficiency in bone marrow-derived DCs (BMDCs) resulted
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia.
Roig B, et al.
Molecular Psychiatry, 12(9), 833-833 (2007)

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