Each batch release of this product has been tested for solubility at 50 mg/mL in ethanol. Turbidity observations are recorded as "clear to slightly hazy," and specific results for each batch are indicated in the Certificate of Analysis.
M4145
Minoxidil
Minoxidil
1 of 2 reviewers received a sample product or took part in a promotion
≥99% (TLC), powder, potassium channel activator
Synonym(s):
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
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25 MG
$91.30
100 MG
$203.00
250 MG
$547.00
500 MG
$967.00
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25 MG
$91.30
100 MG
$203.00
250 MG
$547.00
500 MG
$967.00
About This Item
Empirical Formula (Hill Notation):
C9H15N5O
CAS Number:
Molecular Weight:
209.25
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Minoxidil, ≥99% (TLC)
Quality Level
assay
≥99% (TLC)
mp
272-274 °C (dec.) (lit.)
originator
Johnson & Johnson
SMILES string
NC1=CC(=NC(=N)N1O)N2CCCCC2
InChI
1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Gene Information
human ... KCNJ1(3758)
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Application
Minoxidil has been used as test drug:
- in dermal papilla spheroid model, to study the effect of hair regeneration[1]
- administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury[2]
- administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses[3]
Biochem/physiol Actions
Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.[4]
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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J van der Velden et al.
Cellular and molecular life sciences : CMLS, 55(5), 788-798 (1999-06-24)
To investigate whether during cardiac hypertrophy changes occur in contractile protein composition and in mechanical and energetic properties of the myocardium, contractile protein composition, isometric force and adenosine triphosphate (ATP) consumption were studied in control and hypertrophied guinea-pig hearts. Cardiac
Stefan Sarkovich et al.
Journal of experimental orthopaedics, 10(1), 84-84 (2023-08-22)
Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri-operative function, we evaluated the antifibrotic effect of Minoxidil (MXD) on formation of pyridinoline
Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Gupta AC, et al.
Journal of Cellular Physiology, 233(11), 9015-9030 (2018)
C Löffler-Walz et al.
British journal of pharmacology, 123(7), 1395-1402 (1998-05-14)
1. The binding of [3H]-P1075, a potent opener of adenosine-5'-triphosphate-(ATP)-sensitive K+ channels, was studied in a crude heart membrane preparation of the rat, at 37 degrees C. 2. Binding required MgATP. In the presence of an ATP-regenerating system, MgATP supported
Ilaria Aurigemma et al.
Biochemical and biophysical research communications, 720, 150104-150104 (2024-05-16)
The T-BOX transcription factor TBX1 is essential for the development of the pharyngeal apparatus and it is haploinsufficient in DiGeorge syndrome (DGS), a developmental anomaly associated with congenital heart disease and other abnormalities. The murine model recapitulates the heart phenotype
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Accordingtobibliography,the solubility of minoxidil(CAS 38304-91-5)is 1-7 mg/ml in EtOH.However,you state that the solubility ofSIGMAminoxidil isCLEARCOLORLESS TO VERYSLIGHTLYHAZY FAINT YELLOW SOLUTION AT 50 MG PLUS 1 ML OF EtOH in the specificationsheet.
1 answer-
Helpful?
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Hi، Is the unit of measurement correctly written in milligrams? Shouldn't it have been written gram?
1 answer-
Yes, the milligram quantities listed for the package sizes is correct. The packaged product is not available in gram quantities.
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