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M3893

L-α-Neopentylglycine

Name: <SC>L</SC>-α-Neopentylglycine
Brand: SIGMA

Synonym(s):

γ-Methyl-L-leucine, (S)-2-Amino-4,4-dimethylpentanoic acid, L-γ-Methylleucine

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About This Item

Empirical Formula (Hill Notation):

C₇H₁₅NO₂

CAS Number:

57224-50-7

Molecular Weight:

145.20

MDL number:

MFCD00066079

UNSPSC Code:

12352209

PubChem Substance ID:

329817983

storage temp.

−20°C

SMILES string

[H][C@](N)(CC(C)(C)C)C(O)=O

InChI

1S/C7H15NO2/c1-7(2,3)4-5(8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-/m0/s1

InChI key

LPBSHGLDBQBSPI-YFKPBYRVSA-N

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Synthesis of gamma-methyl-L-leucine (neopentylglycine, Neo) and derivatives suitable for peptide synthesis.

J L Fauchère et al.

International journal of peptide and protein research, 18(3), 249-255 (1981-09-01)

The modified Strecker synthesis of Patel & Worsley was combined with an enzymatic deamidation in the final step, to produce the title compound. The amino acid is a member of the family of the "fat" amino-acids with high lipophilicity and

The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis.

Xuejing Yu et al.

The FEBS journal, 281(1), 391-400 (2013-11-12)

Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been fully explored or exploited owing to the inescapable restrictions of previous

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