Proceedings of the National Academy of Sciences of the United States of America, 96(7), 3688-3693 (1999-03-31)
We have applied in situ atomic force microscopy to directly observe the aggregation of Alzheimer's beta-amyloid peptide (Abeta) in contact with two model solid surfaces: hydrophilic mica and hydrophobic graphite. The time course of aggregation was followed by continuous imaging
Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9712-9717 (2000-08-10)
Production of amyloid-beta protein (Abeta) is initiated by a beta-secretase that cleaves the Abeta precursor protein (APP) at the N terminus of Abeta (the beta site). A recently identified aspartyl protease, BACE, cleaves the beta site and at residue 11
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