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M3819

Sigma-Aldrich

MCA-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys(DNP)-NH2 trifluoroacetate salt

≥95% (HPLC), powder

Synonym(s):

MCA-HQKLVFFAK(DNP)-NH2

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About This Item

Empirical Formula (Hill Notation):
C73H94N16O19 · xC2HF3O2
Molecular Weight:
1499.62 (free base basis)
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

assay

≥95% (HPLC)

form

powder

color

yellow

shipped in

wet ice

storage temp.

−20°C

Amino Acid Sequence

MCA-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-DNP-NH2

Biochem/physiol Actions

α-Secretase substrate I, fluorogenic.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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T Kowalewski et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(7), 3688-3693 (1999-03-31)
We have applied in situ atomic force microscopy to directly observe the aggregation of Alzheimer's beta-amyloid peptide (Abeta) in contact with two model solid surfaces: hydrophilic mica and hydrophobic graphite. The time course of aggregation was followed by continuous imaging
M Farzan et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9712-9717 (2000-08-10)
Production of amyloid-beta protein (Abeta) is initiated by a beta-secretase that cleaves the Abeta precursor protein (APP) at the N terminus of Abeta (the beta site). A recently identified aspartyl protease, BACE, cleaves the beta site and at residue 11

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