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M3633

Sigma-Aldrich

4-Methylumbelliferyl β-D-glucopyranoside

β-glucosidase substrate, fluorogenic, ≥99% (HPLC), powder

Synonym(s):

MUD

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$92.47

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100 MG
$92.47
250 MG
$166.00
500 MG
$294.00
1 G
$467.50
5 G
$1,930.00

About This Item

Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
18997-57-4
Molecular Weight:
338.31
Beilstein/REAXYS Number:
94672
EC Number:
242-736-7
MDL number:
MFCD00063694
UNSPSC Code:
12352204
PubChem Substance ID:
24896859
NACRES:
NA.32

$92.47

List Price$98.90Save 7%
Web-Only Promotion

Available to ship onApril 29, 2025Details

Product Name

4-Methylumbelliferyl β-D-glucopyranoside, β-glucosidase substrate

Quality Level

200

assay

≥99% (HPLC)

form

powder

solubility

DMF: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λex 316 nm; λem 372 nm (pH 9.1)
λex 360 nm; λem 449 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16-/m1/s1

InChI key

YUDPTGPSBJVHCN-YMILTQATSA-N

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Application

4-Methylumbelliferyl β-D-glucopyranoside has been used as substrate:
  • in glucosylceramidase β enzyme activity assay in lysosome-enriched fractions from primary hippocampal neurons[1]
  • in β-glucosidase assay during yeast fermentation[2]
  • to assay glucocerebrosidase 1 (GBA1)-related glucosidase activity in macrophage cell line (RAW)[3]

Biochem/physiol Actions

4-Methylumbelliferyl β-D-glucopyranoside is a synthetic enzymatic substrate for glycosidase.[4] It has been used as substrate for the β- glucosidase from enterococci.[5]

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000438436
0000438436
0000438425
0000438437
0000438437

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Assessing microbial safety of drinking water improving approaches and methods: Improving approaches and methods, 253-253 (2003)
Florent Malard et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(6), 1059-1067 (2015-02-25)
This retrospective report compared the 4-year outcomes of allogeneic stem cell transplantation (allo-SCT) in 651 adult patients with acute myeloid leukemia receiving a reduced-intensity (RIC) or nonmyeloablative conditioning (NMA) regimen according to the type of unrelated donors. These were either
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations
Li H, et al.
Autophagy, 15(1), 113-130 (2019)
An Improved Helferich Method for the alphabeta-Stereoselective Synthesis of 4-Methylumbelliferyl Glycosides for the Detection of Microorganisms
Wei X, et al.
Molecules (Basel), 20(12), 21681-21699 (2015)
HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Tol MJ, et al.
Autophagy, 14(3), 437-449 (2018)
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