M3550
Anti-MAP Kinase Activated Protein Kinase-2 (MAPKAPK-2) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 45 kDa
species reactivity
bovine, mouse, human
technique(s)
microarray: suitable
western blot: 1:2,000 using MDBK whole cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAPKAPK2(9261)
mouse ... Mapkapk2(17164)
General description
MAP Kinase Activated Protein Kinase-2 (MAPKAPK-2) is a protein that belongs to Ser/Thr protein kinase family and is activated by p38 MAPK in response to several signals like mitogenic and stress stimuli. It has a crucial role in phosphorylating LIMK1 and hence plays a vital function in VEGF-A-induced actin reorganization, migration, and tubule formation of endothelial cells. Anti-MAP Kinase Activated Protein Kinase-2 (MAPKAPK-2) antibody can be used to study the differential tissue expression of MAPKAPK-2 and its intracellular localization in normal and neoplastic tissues. Rabbit anti-MAP Kinase Activated Protein Kinase-2 (MAPKAPK-2) antibody reacts specifically with human MAPKAPK-2protein (45 kD).
Immunogen
A synthetic peptide corresponding to amino acids 343-358 of human MAP kinase activated protein kinase 2 (MAPKAPK-2), coupled to KLH. The sequence is identical in mouse MAPKAPK-2.
Application
Anti-MAP Kinase Activated Protein Kinase-2 (MAPKAPK-2) antibody can be used in western blotting (diluted 1:2000) and microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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E Cano et al.
Oncogene, 12(4), 805-812 (1996-02-15)
We recently showed that EGF and anisomycin activate two kinases, p45 and p55, whose distinguishing feature is that their detection in in-gel kinase assays is enhanced by copolymerised poly-Glu/Tyr or poly-Glu/Phe (Cano E, Hazzalin CA and Mahadevan LC, Mol. Cell.
Miho Kobayashi et al.
The EMBO journal, 25(4), 713-726 (2006-02-04)
Vascular endothelial growth factor-A (VEGF-A) induces actin reorganization and migration of endothelial cells through a p38 mitogen-activated protein kinase (MAPK) pathway. LIM-kinase 1 (LIMK1) induces actin remodeling by phosphorylating and inactivating cofilin, an actin-depolymerizing factor. In this study, we demonstrate
A Cuenda et al.
FEBS letters, 364(2), 229-233 (1995-05-08)
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)
J Rouse et al.
Cell, 78(6), 1027-1037 (1994-09-23)
MAPK-activated protein kinase-2 (MAPKAP kinase-2) is activated in vitro by the p42 and p44 isoforms of MAPK (p42/p44MAPK). In several cell lines, however, MAPKAP kinase-2 is activated by sodium arsenite, heat shock, or osmotic stress and not by agonists that
W Rozek et al.
Polish journal of veterinary sciences, 16(4), 663-669 (2013-01-01)
Changes in the level of cellular proteins in cells inoculated with equine influenza virus H7N7 and H3N8 were studied with microarray technique. H3N8 induced pro-apoptotic proteins while H7N7 induced both pro- as well as anti-apoptotic factors. The higher level of
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